tag:blogger.com,1999:blog-79160532007-11-21T14:24:59.817-08:00bloggerBlogger167125tag:blogger.com,1999:blog-7916053.post-5009200303264455902007-11-21T08:41:00.000-08:002007-11-21T14:24:59.842-08:00

Interesting sounding new study: http://www.ncbi.nlm.nih.gov/sites/entrez?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=18025359&dopt=AbstractPlus Title: Successful Treatment of the Erythema and Flushing of Rosacea Using a Topically Applied Selective {alpha}1-Adrenergic Receptor Agonist, Oxymetazoline. Oxymetazoline is an active ingredient used in some nasal sprays to constrict the blood

bloggertag:blogger.com,1999:blog-7916053.post-49938201571636272402007-08-23T06:11:00.000-07:002007-08-23T06:20:21.585-07:00

COL-118, Collagenex's topical (i.e. "cream" based) treatment for the redness and flushing associated with rosacea has had "highly positive" results in their Phase II studies. I was recently wondering what was happening with COL-118 and had started to suspect it was not progressing so this is suprising and pleasing news to me. They are expecting Phase III trials to begin first quarter 2008.

bloggertag:blogger.com,1999:blog-7916053.post-13654978121438310112007-05-03T08:01:00.000-07:002007-05-03T08:09:26.736-07:00

A new paper deals with how to accurately take before and after pictures and maintain consistant colours. Before and after photos of rosacea sufferers or those with facial redness are often of poor quality and dubious in terms of reliability, indeed sometimes it may be deliberate "marketing" in order to try and entice people to the clinic. * Different lighting before / after *

bloggertag:blogger.com,1999:blog-7916053.post-1168514323924056042007-01-11T03:15:00.000-08:002007-01-11T03:44:20.100-08:00

New protective garments that I've been experimenting with recently have revolutionised what outdoor activities I can take part in during winter, especially long-distance hiking which previously I avoided like the plague during the colder months. I wanted to share my experience for anyone else whose face and nose turn red and hurt during and after cold weather exposure. I have learnt that you

bloggertag:blogger.com,1999:blog-7916053.post-1164720309501584212006-11-28T05:19:00.000-08:002006-11-28T05:29:28.630-08:00

New study looks at whether repeated non-ablative IPL or laser exposure causes DNA damage (which may lead to cancer) in an animal model. No tumors were caused or any health affects noted in the mice during the 6-month study, but expression of two potential "markers" of DNA damage were increased - particularly with 1320 Nd:YAG treatments. The authors caution that further studies are needed to

bloggertag:blogger.com,1999:blog-7916053.post-1162293932300980992006-10-31T03:09:00.000-08:002006-10-31T03:28:07.080-08:00

One of the authors, Gal Shaferstein Ph.D, was kind enough to send me a copy of the paper I blogged about last week, "The effects of intense pulsed light (IPL) on blood vessels investigated by mathematical modeling"... Here are some of my observations an an interested observer (but not a doctor!) Re-iterates what I have read previously, that haemoglobin has absorption peaks around 560nm and again

bloggertag:blogger.com,1999:blog-7916053.post-1161959923807762132006-10-27T07:34:00.000-07:002006-10-27T07:38:43.820-07:00

An interesting study that attempts to model effects of IPL on different size blood vessels. Worth noting that small vessels were the most difficult to effectively raise the temperature of to levels for successful coagulation. Abstract: "Lasers Surg Med. 2006 Oct 25; The effects of intense pulsed light (IPL) on blood vessels investigated by mathematical modeling. Baumler W, Vural E,

bloggertag:blogger.com,1999:blog-7916053.post-1158432002017282222006-09-16T11:36:00.000-07:002006-09-16T11:40:02.030-07:00

A recent study looks at the occurrence of carcinogenesis (cancer) in animals exposed to Intense Pulsed Light. Since the introduction of IPL, many have wondered whether there could be the potential to increase likelihood of skin cancer. This is only one step in addressing that question, but an important one. Carcinogenesis related to intense pulsed light and UV exposure: an experimental animal

bloggertag:blogger.com,1999:blog-7916053.post-1156752034912563042006-08-28T00:49:00.000-07:002006-08-28T01:06:24.436-07:00

Clinuvel (was Epitan) has completed a small Phase II trial with patients suffering from Polymorphous Light Eruption (PLE). This is part of their strategy of ensuring targeting relevant dermatological diseases that benefit from increased sun protection via melanin. "We have made a significant step forward in the development of CUV1647, but there are ample challenges ahead” said Clinuvel’s CEO,

bloggertag:blogger.com,1999:blog-7916053.post-1154529660392998722006-08-02T07:31:00.000-07:002006-08-02T07:41:30.923-07:00

An interesting laboratory study that speculates on the possible treatment of rhyinophyma (red, bulbous nose of rosacea, often with excess tissue) with the "breast cancer" drug, tamoxifen (also rarely used to treat retroperitoneal fibrosis). A number of studies appear to have suggested that fibrosis (caused by overexpression of the fibrogenic protein TGF-beta 2?) is implicated in the development

bloggertag:blogger.com,1999:blog-7916053.post-1153927231714828082006-07-26T08:13:00.000-07:002006-07-26T08:20:31.770-07:00

Here's an interesting one. A double-blind, placebo-controlled study on zinc sulfate (100mg three times a day) as a naturopathic rosacea treatment, by the University of Baghdad, Iraq. Good results and minor gastric side-effects in some patients (for what it's worth, my personal experience with zinc is that I suffer gastric problems). The abstract doesn't make clear exactly what symptoms were

bloggertag:blogger.com,1999:blog-7916053.post-1153143910092992432006-07-17T06:40:00.000-07:002006-07-17T06:45:10.126-07:00

Dr. Bitter (creator of the "PhotoFacial" protocol) has submitted a patent application for the use of a topical constrictor, post-IPL treatments, or as a cosmetic lotion (to reduce redness). Most patents don't result in commercial products/treatments being developed, but interesting nonetheless. Topical phenyl-epinephrine Rosacea treatment Quote: Inventors: Bitter, Patrick H. SR.; (Los Gatos,

bloggertag:blogger.com,1999:blog-7916053.post-1152879145409494552006-07-14T05:03:00.000-07:002006-07-14T05:15:27.656-07:00

Migenix, using technology licensed and being developed in partnership with Cutanea Life Sciences, is developing a new topical product for rosacea. It looks to be an anti-inflammatory/anti-microbial (so may be beneficial for those rosacea sufferers with acne), based on "cationic antimicrobial peptides". Phase II trials are due to be completed in 2007. Migenix's financial results and

bloggertag:blogger.com,1999:blog-7916053.post-1151961487276650702006-07-03T14:12:00.000-07:002006-07-03T14:18:07.356-07:00

A new study has been published on red and blue light (using LED's as the non-thermal light source). The study does not use a control group or try and differentiate between red and blue light, and there is even some microdermabrasion thrown in for good measure -- so not a terribly rigorous, scientific approach, in my opinion. That said, it is interesting to see LED therapy continue to generate

bloggertag:blogger.com,1999:blog-7916053.post-1149754175398243092006-06-08T01:08:00.000-07:002006-06-08T01:09:35.413-07:00

Quick tip. FINALLY Yahoo has seen fit to give their yahoo groups service a decent search facility. Now you can search the full rosacea support group

bloggertag:blogger.com,1999:blog-7916053.post-1148144373192286542006-05-20T09:55:00.000-07:002006-05-21T04:14:15.693-07:00

Now that the full paper is published online, this post looks in more detail at topical dobesilate. You can see our previous dobesilate post here, which is also worth reviewing. This is a paper describing a case study of person's response, so that needs to be kept in mind when looking at the results. Here is a link to the full paper, in PDF format, with colour photos: Theraputic Response of

bloggertag:blogger.com,1999:blog-7916053.post-1148131466806117822006-05-20T06:18:00.000-07:002006-05-20T06:24:26.806-07:00

The full paper by P Cuevas et. al is now online as a PDF download: Theraputic Response of Rosacea to Dobesilate We have blogged about rosacea and topical dobesilate before, here. I will post more analysis when I've read the paper in full, so please check back.

bloggertag:blogger.com,1999:blog-7916053.post-1146037446792865822006-04-26T00:36:00.000-07:002006-04-26T01:48:07.986-07:00

This is part one of a two-part post on LED treatment for rosacea. I have asked David C, who posts regularly on rosacea forums online, to share his experiences with LED treatment for rosacea for part one. Part two, coming in a few days, will look at what if any other evidence there is to support this therapy. Here are two photos of David (click the photo to view high-resolution version). Photo 1

bloggertag:blogger.com,1999:blog-7916053.post-1145347207916430982006-04-18T00:41:00.000-07:002006-04-21T03:55:53.400-07:00

Epitan, the company developing a product which prompts tanning (melanin), has rebranded as Clinuvel (a combination of "clinical" and "uv"... apparently!) and renamed the Epitan product CU1674. Regulatory approval requires that their product is demonstrated in over 1000 patients. So far they have trialled it in 167. Their struggle is that you cannot register a medicine for "sunburn" or "tanning"

bloggertag:blogger.com,1999:blog-7916053.post-1144375861823083822006-04-06T18:46:00.000-07:002006-04-06T21:18:22.616-07:00

I blogged about topical application calcium dobesilate and rosacea in November 2005, when this study was published, and said I would write more (but didn't). This week, I received an email from a blog reader who has had experience with using this as a topical with interesting results, so I thought I would revisit! To recap on the original study, "Theraputic Response of Rosacea to Dobesilate" (

bloggertag:blogger.com,1999:blog-7916053.post-1144285571001006172006-04-05T17:58:00.000-07:002006-04-05T18:08:45.066-07:00

(via Perry on rosacea support), Sanrosa, AKA SR-01 (I thought it was SR-101), recently renamed to COL-118, is undergoing a Phase I clinical trial at the Mayo Clinic in Scottsdale, Arizona. Principal investigator is Mark V. Dahl MD, who has published before on rosacea including "Topical Metronidazole Maintains Remissions of Rosacea" They are looking for patients with red cheeks and the clinical

bloggertag:blogger.com,1999:blog-7916053.post-1143294118751049442006-03-25T05:27:00.000-08:002006-03-25T05:41:58.786-08:00

I've been skimming through some of the messages on the acne forums. It is scary how many folks who are taking the high dose accutane for acne, are reporting redness and flushing both during and after their regime. They are then getting diagnosed with rosacea. Is no one putting 1-and-1 together to make 2? Are there any studies on this yet? Not that I have seen. The more I have read on

bloggertag:blogger.com,1999:blog-7916053.post-1142909947517838482006-03-20T18:39:00.000-08:002006-05-17T04:07:15.476-07:00

(picture from http://www.truthaboutets.com) A website, on ETS surgery (http://www.truthaboutets.com) has developed into an interesting resource for those considering ETS. ETS has been widely publicised in the media as a simple, low risk solution for blushers and flushers and even touted by some doctors as a treatment for rosacea. There are many scores of reports from people who feel they have

bloggertag:blogger.com,1999:blog-7916053.post-1142675317998974392006-03-18T01:41:00.000-08:002006-03-18T01:58:27.183-08:00

Kelli, a rosacea sufferer who keeps a diary on her rosacea treatments has posted a series of impressive photos before and after photos during her treatment with low-dose accutane, which she has kindly allowed me to reproduce here. The pictures speak for themselves. Kelli has been taking 10mg a day. Worth noting that the most beneficial effects of accutane on rosacea are low-dose regimes. High

bloggertag:blogger.com,1999:blog-7916053.post-1141211815886591242006-03-01T03:11:00.000-08:002006-03-01T03:16:55.900-08:00

From a Collagenex press release: "CollaGenex is also developing COL-118, utilizing the technology acquired in the SansRosa acquisition, as a preclinical topical compound for the treatment of redness associated with rosacea and other skin disorders. " Under the 2006 financial guidance section: "Research and development expenses: R&D expense is expected to be approximately $17 million and is

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