Thursday, September 29, 2005
Thoughts from a rosaca sufferer of 33 years
Some interesting points in this thoughtful message
http://health.groups.yahoo.com/group/rosacea-support/message/76163
Quote:
"We had just put a man on the moon a few years before my diagnosis. Who
would have thought that I'd still be dealing with rosacea every day
33 years later? Certainly not me. Don't give up living your life
until your face looks perfect. I am sorry and sad that this may
never happen for some of us."
http://health.groups.yahoo.com/group/rosacea-support/message/76163
Quote:
"We had just put a man on the moon a few years before my diagnosis. Who
would have thought that I'd still be dealing with rosacea every day
33 years later? Certainly not me. Don't give up living your life
until your face looks perfect. I am sorry and sad that this may
never happen for some of us."
Sunday, September 18, 2005
Antibiotics throat risk
Been in the news this week:
Acne antibiotics throat bug risk (BBC)
Quote:
"Within the first year, 15% of patients with acne suffered at least one infection. The odds of an infection developing in someone on antibiotics were about 2.15 times greater than in those not on the drugs."
Worth being aware of.
Acne antibiotics throat bug risk (BBC)
Quote:
"Within the first year, 15% of patients with acne suffered at least one infection. The odds of an infection developing in someone on antibiotics were about 2.15 times greater than in those not on the drugs."
Worth being aware of.
Saturday, September 17, 2005
Topical chrysanthellum indicum for rosacea
New study on medline ("chrysanthellum indicum" = "Golden chamomile", a plant with a long history of topical use, for those interested!). Looks like a nice little study from the abstract.
Randomized placebo-controlled trial of a flavonoid-rich plant extract-based cream in the treatment of rosacea.
J Eur Acad Dermatol Venereol. 2005 Sep;19(5):564-568
Authors: Rigopoulos D, Kalogeromitros D, Gregoriou S, Pacouret J, Koch C, Fisher N, Bachmann K, Brown M, Schwarz E, Camel E, Katsambas A
Background Biological research suggests that vascular changes may play a major role in rosacea pathogenesis. Chrysanthellum indicum is a plant-based extract containing a unique combination of phenylpropenoic acids, flavonoids and saponosids, and has a well-documented effect on vascular wall permeability and increase of the mechanical resistance of capillaries. Objective To determine the efficacy and safety of a cream containing 1%C. indicum extract with vitamin P properties in the treatment of rosacea. Methods This study included 246 patients diagnosed clinically as having moderate rosacea. Patients were randomly allocated to C. indicum extract-based cream (n = 125) and placebo (n = 121) groups. Patients were advised to apply the products on their face twice a day for a 12-week period. The patients were examined at the end of each 4-week period. Severity of erythema (graded by reference to six photographs), surface of erythema and rosacea overall severity scores were recorded at each visit on days 0, 28, 56 and 84. Investigators carried out a final efficacy assessment at the end of week 12. Volunteers' final overall efficacy assessment was recorded in a self-administered questionnaire. Adverse events were identified through examination, interview and collection of comments in patients' questionnaires. Results Treatment with the C. indicum extract-based cream resulted in significant improvement (P < 0.05) in severity of erythema, overall rosacea severity compared to baseline and placebo, and investigator and patient overall efficacy assessment scores (P = 0.046 and P = 0.001, respectively) compared with placebo scores. Adverse reactions were mild, and did not differ between the C. indicum extract-based cream and the placebo groups.
Conclusion
Chrysanthellum indicum extract-based cream is an effective and well-tolerated topical agent for the treatment of moderate rosacea. The mode of action of the active ingredient suggests that additional efficacy might be expected from combination with other topical treatments.
Randomized placebo-controlled trial of a flavonoid-rich plant extract-based cream in the treatment of rosacea.
J Eur Acad Dermatol Venereol. 2005 Sep;19(5):564-568
Authors: Rigopoulos D, Kalogeromitros D, Gregoriou S, Pacouret J, Koch C, Fisher N, Bachmann K, Brown M, Schwarz E, Camel E, Katsambas A
Background Biological research suggests that vascular changes may play a major role in rosacea pathogenesis. Chrysanthellum indicum is a plant-based extract containing a unique combination of phenylpropenoic acids, flavonoids and saponosids, and has a well-documented effect on vascular wall permeability and increase of the mechanical resistance of capillaries. Objective To determine the efficacy and safety of a cream containing 1%C. indicum extract with vitamin P properties in the treatment of rosacea. Methods This study included 246 patients diagnosed clinically as having moderate rosacea. Patients were randomly allocated to C. indicum extract-based cream (n = 125) and placebo (n = 121) groups. Patients were advised to apply the products on their face twice a day for a 12-week period. The patients were examined at the end of each 4-week period. Severity of erythema (graded by reference to six photographs), surface of erythema and rosacea overall severity scores were recorded at each visit on days 0, 28, 56 and 84. Investigators carried out a final efficacy assessment at the end of week 12. Volunteers' final overall efficacy assessment was recorded in a self-administered questionnaire. Adverse events were identified through examination, interview and collection of comments in patients' questionnaires. Results Treatment with the C. indicum extract-based cream resulted in significant improvement (P < 0.05) in severity of erythema, overall rosacea severity compared to baseline and placebo, and investigator and patient overall efficacy assessment scores (P = 0.046 and P = 0.001, respectively) compared with placebo scores. Adverse reactions were mild, and did not differ between the C. indicum extract-based cream and the placebo groups.
Conclusion
Chrysanthellum indicum extract-based cream is an effective and well-tolerated topical agent for the treatment of moderate rosacea. The mode of action of the active ingredient suggests that additional efficacy might be expected from combination with other topical treatments.
Thursday, September 15, 2005
Measuring Eyrthema after IPL
David has started his own Rosacea News blog and has already made some interesting posts.
Today's about measuring Erythema post IPL was fascinating. David highlights this paper which I hadn't seen before.
The authors of the paper try to objectively measure IPL's effect on facial redness. They conclude:
"The scanning laser Doppler demonstrated a 30% decrease in blood flow (P < 0.05).
I would like to see more studies in this vein, with more patients.
Today's about measuring Erythema post IPL was fascinating. David highlights this paper which I hadn't seen before.
The authors of the paper try to objectively measure IPL's effect on facial redness. They conclude:
"The scanning laser Doppler demonstrated a 30% decrease in blood flow (P < 0.05).
I would like to see more studies in this vein, with more patients.
